Job Descrption
Open Date
01/11/2024, 10:00
Close Date
24/11/2024, 23:55
Research Institute
MRC Laboratory of Medical Sciences
As this job does not fulfil the UK Government minimum salary criterion for obtaining sponsored migrant worker status we will be unable to apply for sponsorship for anyone not eligible to work in the UK. At interview, all shortlisted candidates are required to bring with them identification documents and original documents that prove they hold or can obtain the right to work in the UK. You can check your eligibility here: https://www.gov.uk/check-uk-visa/y
Research Institute / Unit Information
The LMS is a world-class research laboratory where scientists and clinicians collaborate to advance the understanding of biology and its application to medicine. Funded by the MRC as part of UK Research and Innovation, the LMS has a collaborative working culture and new state-of-the-art building based in the heart of West London in the Hammersmith Hospital Campus (W12).
The LMS... aims to deliver transdisciplinary team science, in synergistic interaction with Imperial College and the wider national research environment.
UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at www.ukri.org
Band
MRC - 5
Location
London
Salary
£29,808 – £31,671 plus London allowances (£3,913 & £1,472) per annum
Contract Type
Fixed Term
Job Type
Science
Full Time / Part Time
Full Time
Contract Length
3 years
Job Description
Overall purpose:
A new opportunity has arisen for a Research Technician in the Metabolism in Immunity, Cancer and Ageing (MICA) group headed by Dr Nazma Malik.
Main duties / key responsibilities:
• Participate in laboratory experiments aimed at understanding the influence of metabolism in immunity, particularly cancer immune responses
• Working as part of a small dynamic team and under the guidance of Dr Malik, you will provide support to the MICA group
• Application of molecular cloning techniques to generate selection of DNA constructs
• Employ Crispr/Cas9 methods for generation of knock out/knock in cell lines
• Routine maintenance of tissue culture cells lines
• Undertake molecular and cellular biology experiments where necessary (PCR, qPCR, Western blotting and imaging)
• Provide support with ordering, lab stocks and organization of spaces, as well as ensuring that equipment/apparatus/systems etc in MICA group are maintained, serviced and repaired as required
The appointee will:
• Conduct research as part of the group’s core program
• Demonstrate strong motivation, ability to work independently and in a team
• Take an active part in the academic activities of the Group including group meetings, group journal clubs, training and organisational aspects
This is an MRC funded and laboratory-based position to support other scientists in early or changed career training and to help establish them as successful research scientists in their chosen field. We offer a highly attractive benefits package including competitive salary and excellent holiday entitlement.
Working relationships:
The post-holder will report directly to Dr Malik.
Person Specification
Education / Qualifications / Training required (will be assessed from application form):
Essential:
• BSc (or equivalent) qualification in biological sciences, biochemistry, molecular biology, cell biology or related discipline
Desirable:
• MSc, MRes or PhD in biochemistry, molecular or cell biology in cancer, immunology or a related discipline
Previous work experience required (will be assessed from application form and at interview):
Essential:
• Proficiency in molecular cloning techniques including conventional and Gateway Recombination, TOPO etc
• Understanding and experience of Crispr/Cas9 approahces to edit or perturb genes including knock outs and knock ins
• Experience in biochemical techniques such as western blotting, DNA/RNA extraction, qPCR etc
• Tissue culture experience and handling of cell lines
• Background in biochemistry and metabolic, cancer and/or immune signalling
• Good written communication skills in English
Desirable:
• Experience in imaging and image analysis
• Proteomics experience
• RNAseq and bioinformatics experience
• Experience of working with in vivo mouse models
Personal skills / Behaviours / Qualities (will be assessed at interview):
Essential:
• Good verbal communication skills in English
• Excellent organisational ability to support lab maintenance
• High level of motivation and drive
• Ability to work both independently and as part of a team
• Ability and eagerness to learn new concepts and acquire new skills in biology quickly, and to seek novel and creative solutions to scientific problems
Further Information
Applicants should submit a CV, a brief cover letter describing scientific interests and names and contacts of two scientific references. Please quote reference number LMS 2519.
Applications without a supporting covering letter will not be considered.
The MRC is a unique working environment where scientific researchers and professional support staff can actively partake in world class innovation and collaboration opportunities and their skills and knowledge through accessing a wide catalogue of training & development, including professional registration with the Science Council.
In addition, MRC (part of UKRI) provides its community of employees access to a whole host of useful benefits, including a defined benefit pension scheme and excellent holiday entitlement (30 days plus 2.5 privilege days & 8 bank holidays), family friendly policies (6 months full pay maternity & adoption leave), a range of shopping/travel discounts, access to our Employee Assistant Programme Scheme, Health and Wellbeing Support and a salary sacrifice cycle to work scheme. Please follow this link to find out more - Benefits
Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We warmly invite people from diverse backgrounds and heritage, including people who identify as having a disability, to apply for a role that excites them. As "Disability Confident" employers, we guarantee to interview all applicants who have disclosed they have a disability and who meet the minimum criteria for the vacancy.
UKRI supports research in areas that include animal health, agriculture and food security, and bioscience for health which includes research on animals, genetic modification and stem cell research. Whilst you may not have direct involvement in this type of research, you should consider whether this conflicts with your personal values or beliefs.
We will conduct a full and comprehensive pre-employment check as an essential part of the recruitment process on all individuals that are offered a position with UKRI. This will include a security check and an extreme organisations affiliation check. The role holder will be required to have the appropriate level of security screening/vetting required for the role. UKRI reserves the right to run or re-run security clearance as required during the course of employment
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